Naptumomab (ABR-217620) is a tumor-targeted superantigen (TTS) fusion protein consisting of a Fab fragment targeting the 5T4 oncofetal antigen and a modified staphylococcal enterotoxin A (SEA/E-120). This product specifically recognizes 5T4 protein expressed on various solid tumors via the Fab fragment and potently activates T cells (primarily by binding to the TCR Vbeta chain) through the superantigen component, inducing T cell-mediated cytotoxicity against tumor cells. It bypasses major histocompatibility complex (MHC) restriction to directly recruit and activate a large number of effector T cells into the tumor microenvironment.
CAS Number:
[1412892-09-1]
Target:
Others
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