L17E, a cationic amphiphilic peptide with endosomolytic properties, selectively disrupts the membranes of late endosomes (LEs) in an acidic environment and prevents TS5-p45-induced apoptosis in a dose-dependent manner. This peptide is internalized by cells and directed to LEs, where it compromises LE integrity and facilitates the release of their contents into the cytosol. L17E serves as a tool for probing the endosomal protein trafficking pathway [1].
Molecular Weight:
2860.4
CAS Number:
[2305578-13-4]
Formula:
C134H219N37O32
T81966
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