JBSNF-000028 is an orally active inhibitor of nicotinamide N-methyltransferase (NNMT), with inhibitory concentration (IC50) values of 0.033 µM for human NNMT (hNNMT), 0.19 µM for monkey NNMT (mkNNMT), and 0.21 µM for mouse NNMT (mNNMT). This compound may be utilized in the study of metabolic disorders [1].
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