ICMT-IN-54 (compound 7c), an adamantyl analogue, serves as an ICMT inhibitor with an IC50 value of 12.4 µM, targeting the methylation process facilitated by ICMT. It specifically inhibits the methylation of BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) in Saccharomyces cerevisiae expressing ICMT, marking an indirect inhibition of ICMT-mediated methylation [1].
Molecular Weight:
487.74
CAS Number:
[908856-14-4]
Formula:
C29H45NO3S
Target:
Others|||Transferase
T82088
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