Avacopan (CCX168) is a C5aR antagonist (IC50=0.1 nM) with selective and oral activity. Avacopan blocks the action of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a mouse model of AAV. Avacopan can be used to treat anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis.
Molecular Weight:
581.64
Purity:
97.00%
CAS Number:
[1346623-17-3]
Formula:
C33H35F4N3O2
Target:
Complement System
T8223
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