D359-0396, an orally active NLRP3 inflammasome inhibitor, mitigates pyroptosis and reduces IL-1beta release in macrophages by inhibiting the oligomerization of NLRP3, ASC, and the cleavage of GSDMD. The compound is effective in alleviating Experimental Autoimmune Encephalomyelitis (EAE) and enhances survival following septic shock in mice [1].
Molecular Weight:
400.47
CAS Number:
[1031977-31-7]
Formula:
C24H24N4O2
Target:
Pyroptosis|||NOD-like Receptor (NLR)
T82621
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