Tat-IKIP (46-60) , Tat-Inhibitor of NF-kappaB Kinase-interacting Peptide
F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-kappaB kinase-interacting peptide (IKIP). It effectively blocks LPS-induced phosphorylation of IkappaB kinase alpha (IKKalpha) and IKKbeta, along with the nuclear translocation of NF-kappaB (p65) in mouse peritoneal macrophages at 5 µM concentration. F1, administered at 5 mg/kg in vivo, significantly reduces IL-6, TNF-alpha, and IL-1beta serum levels and enhances survival in a mouse sepsis model induced by LPS.
Molecular Weight:
3189.88
Formula:
C145H246N48O31S.XCF3COOH
T83670
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