Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib exhibits inhibitory activity against KRAS G12C mutant tumors.
Molecular Weight:
604.12
Purity:
99.10%
CAS Number:
[2326521-71-3]
Formula:
C32H35ClFN7O2
Target:
Ras|||Kras
T8369
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