[Leu144, Arg147]-PLP (139-151) TFA

Product Overview

• Article Name: [Leu144, Arg147]-PLP (139-151) TFA
• Biozol Catalog Number: TGM-T83690
• Supplier Catalog Number: T83690
• Alternative Catalog Number: TGM-T83690-1MG,TGM-T83690-5MG,TGM-T83690-10MG,TGM-T83690-25MG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: [Leu144, Arg147] Proteolipid Peptide (139-151) , H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH

Product Description

[Leu144,Arg147]-PLP (139-151) is a mutated fragment of the myelin proteolipid protein (PLP), featuring substitutions of tryptophan to leucine and histidine to arginine at positions 144 and 147, respectively. Immunizing mice with this peptide (50 µg) mixed in complete Freunds adjuvant (CFA) elevates IL-4 levels in the spleen. While it suppresses Th1 cell activation in vitro, it does not do so in vivo, instead, it promotes the development of regulatory T cells. Preimmunization with [Leu144, Arg147]-PLP (139-151) postpones the onset of experimental autoimmune encephalomyelitis (EAE) triggered by encephalitogenic peptides from PLP (178-191), myelin oligodendrocyte glycoprotein (MOG) (92-106), or myelin basic protein (MBP) in mice.

Product Properties

• Molecular Weight: 1467.71
• Formula: C67H110N20O17.XCF3COOH

Images

T83690