PapRIV, a quorum-sensing heptapeptide derived from B. cereus, undergoes synthesis as a 48-amino acid polypeptide. This compound is secreted and then extracellularly processed by NprB proteases into its active form. At concentrations ranging from 1-25 µM, PapRIV triggers the production of IL-6 and TNF-alpha, as well as NF-kappaB translocation, specifically in BV-2 microglia cells.
Molecular Weight:
843.9
Formula:
C38H53N9O13.XCF3COOH
T83734
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