Tiger17, a cyclic peptide derivative of tigerinin-RC1 and tigerinin-RC2-antimicrobial peptides from the crab-eating frog (F. cancrivora) skin secretions-enhances HaCaT keratinocytes and human skin fibroblasts proliferation at 5 to 20 µg/ml concentrations, and promotes HaCaT cell migration at 20 µg/ml. Additionally, Tiger17 augments RAW 264.7 macrophages recruitment and secretion of TGF-beta1 and IL-6. When topically applied at 20 µg/ml, it accelerates wound closure and re-epithelialization in a mouse model of full-thickness dermal wounds.
Molecular Weight:
1376.7
Formula:
C62H97N21O11S2.XCF3COOH
T83744
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