8-Chloroadenosine-5-triphosphate sodium, CAS [[793671-47-3]]

Product Overview

• Article Name: 8-Chloroadenosine-5-triphosphate sodium, CAS [[793671-47-3]]
• Biozol Catalog Number: TGM-T83786
• Supplier Catalog Number: T83786
• Alternative Catalog Number: TGM-T83786-2700UG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: 8-chloro ATP

Product Description

8-Chloroadenosine-5-triphosphate (8-chloro ATP), a potent metabolite of the anticancer agent 8-chloro cyclic AMP (cAMP) and a nucleotide derivative, is produced through the biotransformation of 8-chloro cAMP into 8-chloroadenosine, followed by mono- and diphosphate intermediates. Accumulating for up to 12 hours after the administration of 8-chloro cAMP or 8-chloroadenosine, 8-chloro ATP inhibits cell growth, diminishes endogenous ATP levels, and reduces RNA synthesis without affecting DNA synthesis in multiple myeloma cells derived from patients. Moreover, it obstructs topoisomerase II-alpha-mediated relaxation of supercoiled pUC19 DNA at concentrations ranging from 1.5 to 8 mM and decreases topoisomerase II-alpha-enhanced ATP hydrolysis by 50% at a concentration of 1 mM in K562 human myelocytic leukemia cells.

Product Properties

• Molecular Weight: 629.55
• CAS Number: [793671-47-3]
• Formula: C10H11ClN5O13P3.4Na
• Target: Topoisomerase|||Others

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T83786