HUP-55 is a prolyl endopeptidase inhibitor with an IC50 of 5 nM, shown to mitigate alpha-synuclein dimerization in Neuro2a cells, stimulate autophagy in HEK293 cells, and lower hydrogen peroxide-evoked reactive oxygen species (ROS) production in SH-SY5Y cells at a 10 µM concentration. Additionally, administration of HUP-55 at a dosage of 10 mg/kg reduces ipsilateral paw use and diminishes striatal oligomeric alpha-synuclein concentrations in a Parkinsons disease mouse model, which is induced through adenoviral vector-mediated overexpression of alpha-synuclein (AAV-alphaSyn).
Molecular Weight:
295.38
Formula:
C18H21N3O
Target:
Others
T83875
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