S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine, CAS [[364083-21-6]]

Product Overview

• Article Name: S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine, CAS [[364083-21-6]]
• Biozol Catalog Number: TGM-T83898
• Supplier Catalog Number: T83898
• Alternative Catalog Number: TGM-T83898-5MG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: SFN-Cys , D,L-Sulforaphane-L-cysteine

Product Description

S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SFN-Cys) is an isothiocyanate derivative, functioning as an active metabolite of sulforaphane, a class I and II histone deacetylase (HDAC) inhibitor, and anticancer agent. This compound is generated from sulforaphane through intermediates - DL-sulforaphane glutathione and sulforaphane cysteinylglycine - via the mercapturic acid pathway enzymes. At a concentration of 20 µM, SFN-Cys diminishes invasion and migration of U87MG and U373 MG glioblastoma cells as observed in wound healing and chamber assays. Furthermore, at 45 µM, it significantly lowers the expression of alpha-tubulin, betaIII-tubulin, stathmin 1, and X-linked inhibitor of apoptosis (XIAP), and also reduces cell density in paclitaxel-resistant A549 lung cancer cells (A549/T). Additionally, when used at 30 µM, SFN-Cys prompts apoptosis and cell cycle arrest at the G2/M phase in U87MG and U373 MG cells.

Product Properties

• Molecular Weight: 298.45
• CAS Number: [364083-21-6]
• Formula: C9H18N2O3S3
• Target: Others|||Drug Metabolite

Images

T83898