DA ZP1 (diacetylated Zinpyr1), a highly sensitive fluorogenic Zn(II) sensor (KdZn2+= 0.6 nM), efficiently images and isolates pancreatic beta-cells and beta-like cells in vitro and purifies live stem cell-derived beta-like cells. It also enables imaging of transplanted islet grafts and endogenous mouse islets in vivo. DA ZP1 is initially non-fluorescent, however, its interaction with Zn(II) ions triggers hydrolytic cleavage of the acetyl groups, creating a robust fluorescent signal with excitation and emission maxima (lambda) at 490 nm and 522 nm, respectively.
Molecular Weight:
907.81
CAS Number:
[1816254-69-9]
Formula:
C50H40Cl2N6O7
Target:
Others
T83928
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