VU 0546110, a selective inhibitor of the sperm-specific potassium channel SLO3 (IC50= 64 µM), demonstrates 40-fold selectivity over SLO1. It effectively blocks both heterologous SLO3 currents and endogenous K+ currents, inhibiting sperm hyperpolarization and preventing hyperactivated mobility.
Molecular Weight:
461.64
CAS Number:
[1421523-00-3]
Formula:
C24H31NO4S2
Target:
Others|||Potassium Channel
T83960
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