17(R)-Resolvin D1 methyl ester, CAS [[937738-64-2]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T84455
Supplier Catalog Number:
T84455
Alternative Catalog Number:
TGM-T84455-10MG,TGM-T84455-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
Alternative Names:
Aspirin-triggered-Resolvin D1 methyl ester
17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that equivalently inhibits human polymorphonuclear leukocyte migration across the endothelium (EC50= ~30 nM), a precursor to acute inflammation. Unlike RvD1, it resists rapid degradation by eicosanoid oxidoreductases. In a mouse peritonitis model, 17(R)-RvD1 dose-dependently reduces leukocyte infiltration, achieving up to a 35% decrease with a 100 ng dose. Additionally, its methyl ester derivative, designed to enhance its pharmacokinetic and distribution properties as a more lipophilic prodrug, can be converted back into the active acid form by intracellular esterases.
Molecular Weight:
390.5
CAS Number:
[937738-64-2]
Formula:
C23H34O5
Target:
Others|||Endogenous Metabolite
T84455
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