13,14-dihydro-15-keto Prostaglandin E2, CAS [[363-23-5]]

Product Overview

• Article Name: 13,14-dihydro-15-keto Prostaglandin E2, CAS [[363-23-5]]
• Biozol Catalog Number: TGM-T84586
• Supplier Catalog Number: T84586
• Alternative Catalog Number: TGM-T84586-1MG, TGM-T84586-5MG, TGM-T84586-10MG
• Manufacturer: TargetMol
• Category: Biochemikalien
• Alternative Names: 13,14-dihydro-15-keto PGE2

Product Description

13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) serves as the predominant metabolite of PGE2 in plasma, created through a 15-keto PGE2 intermediate by the action of 15-oxo-PG delta13 reductase. Unlike its precursor PGE2, this compound exhibits poor binding affinity towards EP2 and EP4 PGE2 receptors (Ki values of 12 and 57 µM, respectively) in CHO cells and fails to stimulate adenylate cyclase activity therein (EC50s >18 and >38 µM, respectively). Concentrations of 13,14-dihydro-15-keto PGE2 are notably higher in the plasma of pregnant women during their third trimester and at labor and delivery stages, whereas its levels are found to be reduced in the tumor tissues of patients with non-small cell lung cancer (NSCLC) compared to adjacent healthy tissue.

Product Properties

• Molecular Weight: 352.5
• CAS Number: [363-23-5]
• Formula: C20H32O5
• Target: Others|||5-HT Receptor|||Endogenous Metabolite