()9(10)-DiHOME, CAS [[263399-34-4]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T84633
Supplier Catalog Number:
T84633
Alternative Catalog Number:
TGM-T84633-10MG,TGM-T84633-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
Alternative Names:
Leukotoxin diol
()9(10)-DiHOME, the diol derivative of ()9(10)-EpOME-a cytochrome P450-derived epoxide of linoleic acid also known as leukotoxin-is formed through the action of soluble epoxide hydrolase (sEH) in neutrophils. It exhibits toxicity towards Sf21 cells expressing sEH as well as tolacZ-expressing control cells, differing from leukotoxin which only harms sEH-containing cells. Furthermore, combined exposure to 9(10)- and 12(13)-DiHOME leads to cell death in rabbit renal proximal tubule cells by disrupting mitochondrial respiration, and causes lung injury, respiratory distress, and mortality in mice, highlighting its role as a toxic lipid mediator. Specifically, 9(10)-DiHOME has been associated with acute respiratory distress syndrome (ARDS), a severe and often deadly complication in patients with major burns. Elevated levels of this compound have been detected in the bronchoalveolar lavage fluid (BALF) of women, but not men, with chronic obstructive pulmonary disease (COPD), and its levels are also increased in patients with allergic asthma, indicating its significance in respiratory conditions.
Molecular Weight:
314.5
CAS Number:
[263399-34-4]
Formula:
C18H34O4
Target:
Others|||DNA/RNA Synthesis|||NF-kappaB|||PPAR
T84633
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