Prostaglandin D2 (PGD2) is a primary enzymatic prostaglandin derived from PGH2 and is abundantly produced in the cerebrospinal fluid (CSF) by the lipocalin-type PGD synthase, and peripherally by myeloid cells such as mast cells and basophils via a hematopoietic-type PGD synthase. PGD2 is chemically unstable and presents challenges for use and analysis due to its brief in vivo half-life. delta12-PGD2, an initial decomposition product of PGD2, acts as an intermediate in the pathway to delta12-PGJ2, a cyclopentenone prostaglandin known for its antimitotic and carcinogenic properties. The metabolism of delta12-PGD2 involves the addition of thiol nucleophiles, a common pathway for many cyclopentenone prostaglandins.
Molecular Weight:
352.5
CAS Number:
[64072-89-5]
Formula:
C20H32O5
Target:
Others
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