KH-4-43, an inhibitor of the E3 CRL4 ligase complex, demonstrates anticancer activity by targeting the core of the E3 CRL4. It exhibits a binding affinity (Kd) of 83 nM to the E3 ROC1-CUL4A CTD and 9.4 µM to the closely related ROC1-CUL1 CTD [1].
Molecular Weight:
422.74
CAS Number:
[2813310-07-3]
Formula:
C19H10ClF3N2O4
Target:
Others|||E1/E2/E3 Enzyme
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