(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCalpha, 28 nM for PKCbetaI, 30 nM for PKCbetaII, 36.5 nM for PKCgamma, and 108.3 nM for PKCepsilon, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].
Molecular Weight:
489.01
CAS Number:
[1781828-85-0]
Formula:
C28H29ClN4O2
Target:
Others|||PKC
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