PEG-bis-amine (MW 8000) is utilized to synthesize folate-conjugated polymeric micelles, encapsulating the insoluble anticancer agent 9-nitrocamptothecin. These folic acid-conjugated polymer micelles serve as efficient carriers that not only evade macrophages but also facilitate the folate receptor (FR)-mediated endocytosis in tumor cells, enhancing drug delivery.
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