Cytarabine 5'-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase alpha, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.
Molecular Weight:
323.198
CAS Number:
[7075-11-8]
Formula:
C9H14N3O8P
Target:
Others|||Drug Metabolite|||DNA/RNA Synthesis
T84932
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