SLP7111228 is a potent, selective SPHK1 inhibitor with Ki values of 0.048 µM for SPHK1 and >10 µM for SPH2K, showing a concentration-dependent reduction of sphingosine-1-phosphate (S1P) in U937 cells without affecting sphingosine levels. In vivo, it dose-dependently lowers S1P blood levels in rats.
Molecular Weight:
420
CAS Number:
[1449768-48-2]
Formula:
C22H34ClN5O
Target:
Others
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