Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe.
Molecular Weight:
438.65
Purity:
96.48%
CAS Number:
[300815-04-7]
Formula:
C13H14Cl3N7O4
Target:
APC/C
T8561
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