Antitumor agent-138 (compound 5b), with an IC 50 of 1.87 µM, inhibits tubulin polymerization at the tubulin colchicine-binding sites. It arrests the cell cycle at the G2/M phase and induces apoptosis in MCF-7 cells. Additionally, this compound suppresses cell migration and angiogenesis [1].
Molecular Weight:
367.4
CAS Number:
[2975168-22-8]
Formula:
C20H21N3O4
Target:
Apoptosis|||Microtubule Associated
T85704
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