CNB-001 is a potent inhibitor of 5-lipoxygenase (5-LOX) that reduces 5-LOX expression while enhancing proteasome activity. It also increases phosphorylation of eIF2alpha and levels of HSP90 and ATF4 in Alzheimers disease transgenic mice, thereby limiting soluble Abeta and ubiquitinated aggregated protein accumulation. Additionally, CNB-001 maintains synapse-associated protein expression and improves memory, making it a valuable compound for Alzheimers disease research [1].
Molecular Weight:
440.49
CAS Number:
[1019110-87-2]
Formula:
C27H24N2O4
Target:
Lipoxygenase
T86070
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