CZL80 is a brain-penetrant caspase-1 inhibitor with an IC50 of 0.01 µM that is used to study febrile seizures and subsequent epileptogenic susceptibility. CZL80 reduces neuronal excitability, decreases the incidence of febrile seizure generation at 7.5 mg/kg intravenously, and mitigates long-term neurological dysfunction following photothrombosis, establishing CZL80 as a valuable tool for neuroinflammation, seizure biology, and stroke-induced pathology.
Molecular Weight:
366.39
Purity:
99.48%
CAS Number:
[313482-91-6]
Formula:
C19H14N2O4S
Target:
Caspase
T86155
T86155
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