DNA-PK-IN-12 (compound 31t), an orally active inhibitor of DNA-PK, demonstrates potent inhibition with an IC 50 of 0.1 nM. It effectively impedes Hct116 cell growth and colony formation, displaying an IC 50 of 33.28 µM, and exhibits antitumor activity in vivo [1].
Molecular Weight:
420.47
CAS Number:
[2792146-91-7]
Formula:
C21H24N8O2
Target:
DNA-PK
T86289
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