Fasudil mesylate (HA-1077, AT877) is a nonspecific, orally active inhibitor of RhoA/ROCK, exhibiting additional inhibitory effects on protein kinases with a K i of 0.33 µM for ROCK1. It shows IC 50 values of 0.158 µM for ROCK2, and 4.58 µM, 12.30 µM, and 1.650 µM for PKA, PKC, and PKG, respectively. Furthermore, Fasudil mesylate acts as a potent Ca 2+ channel antagonist and vasodilator, enhancing its pharmacological profile [1] [2] [3] [4] [5] [6].
Molecular Weight:
387.47
CAS Number:
[1001206-62-7]
Formula:
C15H21N3O5S2
Target:
Autophagy|||ROCK|||Calcium Channel|||PKC|||PKA
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