FGFR1 inhibitor-11 (compound 5g) effectively targets and binds to FGFR1, subsequently inhibiting the downstream signaling pathways ERK1/2 and IkappaBalpha/NF-kappaB, which results in the suppression of RANKL-induced osteoclastogenesis. This compound also exhibits oral bioactivity [1].
Molecular Weight:
358.39
CAS Number:
[2157482-40-9]
Formula:
C23H18O4
Target:
FGFR
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