Compound AK-2, also known as hAChE/hBACE-1-IN-4, is a quinazoline derivative that demonstrates significant inhibitory activity against the enzymes hAChE and hBACE-1 (hAChE, IC 50 = 0.283 µM, hBACE-1, IC 50 = 0.231 µM). This compound also shows potential in inhibiting Abeta aggregation and possesses characteristics such as non-neurotoxicity, blood-brain barrier permeability, and oral activity, making it a valuable agent for research in Alzheimers disease [1].
Molecular Weight:
364.44
CAS Number:
[229476-71-5]
Formula:
C21H24N4O2
Target:
Cholinesterase (ChE)|||Beta Amyloid
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