Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.
Molecular Weight:
560.594
Purity:
99.95%
CAS Number:
[2296729-00-3]
Formula:
C30H30F2N6O3
Target:
Ras|||Kras
T8684
T8684
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