MRK-898, an orally active modulator of the GABA(A) receptor, selectively interacts with the alpha1, alpha2, alpha3, and alpha5 subunits, displaying K i values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. It is noteworthy that the alpha1-containing receptors of GABA(A) are classified as sedative, whereas receptors containing alpha2 and/or alpha3 are designated as anxiolytic subtype(s) [1].
Molecular Weight:
400.3
CAS Number:
[461450-30-6]
Formula:
C20H9F5N4
Target:
GABA Receptor
T86930
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