NLRP3-IN-25 (compound 32), an orally available NLRP3 inhibitor, exhibits anti-inflammatory properties by attenuating renal injury in a mouse model of doxorubicin-induced glomerulonephritis and inhibiting IL-1beta secretion in THP-1 cells, with an IC 50 value of 21 nM [1].
Molecular Weight:
448.42
CAS Number:
[2660230-90-8]
Formula:
C17H19F3N4O5S
Target:
Interleukin|||NOD-like Receptor (NLR)
T87016
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