Perforin-IN-2, a benzosulfonamide perforin inhibitor, mitigates transplant rejection in allogeneic bone marrow or stem cell transplantation. It binds to plasma proteins with a binding rate of 99.8%. In vivo, a concentration higher than 900 µM is required for optimal perforin inhibition. Perforin-IN-2 effectively inhibits the lytic activity of recombinant perforin on Jurkat T leukemia cells, with an IC50 of 6.65 µM, and also prevents the death of K562 leukemia target cells [1].
Molecular Weight:
506.55
CAS Number:
[1567836-70-7]
Formula:
C24H18N4O5S2
Target:
Others
T87130
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