MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg).
Molecular Weight:
345.37
CAS Number:
[2099014-23-8]
Formula:
C20H16FN5
Target:
EGFR|||JAK|||GSK-3|||IGF-1R|||PI3K
T87974
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