MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-beta, induces tumor regression, and has long-lasting anti-tumor immunity. [3]
Molecular Weight:
294.32
Purity:
97.87%
CAS Number:
[129425-81-6]
Formula:
C14H14O5S
Target:
STING
T8798
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