TLR8 agonist9 (Compound II-77) functions as an agonist for Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 µM. This compound is stable in human and mouse plasma and effectively induces the secretion of the cytokine TNFalpha with an EC50 of less than 1 µM. In the MC38-HER2 xenograft mouse model, TLR8 agonist9 demonstrates significant antitumor activity, achieving a tumor growth inhibition (TGI) rate of 97%.
Molecular Weight:
725.79
CAS Number:
[3034750-61-0]
Formula:
C38H43N7O8
Target:
TLR
T88096
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