Anticanceragent 235 (Compound 49) functions as a modulator of the PI3K/AKT/mTOR signaling pathway, enhancing reactive oxygen species (ROS) production and reducing mitochondrial membrane potential, thereby inhibiting the proliferation of cancer cell lines HCT116, Caco-2, AGS, and SMMC-772 with IC50 values ranging from 0.35 to 26.9 µM. Additionally, it induces apoptosis and causes cell cycle arrest at the G2/M phase in HCT-116 cells.
Molecular Weight:
296.75
CAS Number:
[2411108-21-7]
Formula:
C17H13ClN2O
Target:
Reactive Oxygen Species|||Akt|||Apoptosis|||PI3K
T88484
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