C3N-Dbn-Trp2 is an inhibitor of the ATP-binding cassette transporter ABCB1. It inhibits the efflux of Rhodamine 123 mediated by ABCB1 in HEK293T and HCT-15 cells, with IC50 values of 5.9 µM and 2.2 µM, respectively. Additionally, C3N-Dbn-Trp2 inhibits the efflux of Doxorubicin, thereby enhancing the cytotoxicity of Doxorubicin in cells expressing ABCB1.
Molecular Weight:
552.66
CAS Number:
[2631659-57-7]
Formula:
C36H32N4O2
Target:
P-gp
T88512
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