SBN-284 (compound 3x) acts as a dual inhibitor of cholinesterases (Cholinesterases) and NLRP3 inflammasomes, demonstrating blood-brain barrier permeability. It exhibits IC50 values of 0.37, 0.31, and 0.29 µM against EeAChE, hAChE, and eqBChE respectively, and an EC50 value of 1 µM against NLRP3. SBN-284 is utilized in Alzheimers disease research.
Target:
NOD-like Receptor (NLR)|||Cholinesterase (ChE)
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