PI3K-IN-55 (Compound 6a) serves as a potential inhibitor of PI3K. It modulates the PI3K/Akt/p53 signaling pathway and inhibits proliferation in cancer cell lines A549, Hela, HepG2, MCF-7, and HT-29, with IC50 values ranging from 1.03 to 6.78 µM. Additionally, PI3K-IN-55 induces apoptosis in MCF-7 cells.
Target:
Apoptosis|||PI3K
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