PARP1/2-IN-3 (Compound 29) is an orally effective inhibitor of PARP1 and PARP2, exhibiting IC50 values of 0.2235 nM and <0.001 nM, respectively. It inhibits the proliferation of Capan-1 wild-type, AZD2281-resistant, and BMN673-resistant cells, with IC50 values ranging from 1.82 to 9.98 nM. Furthermore, PARP1/2-IN-3 demonstrates anti-tumor activity in mice.
Molecular Weight:
484.48
CAS Number:
[3032451-58-1]
Formula:
C26H21FN6O3
T88960
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