Compound 5c (Anticonvulsant agent 5) exhibits high affinity for GABAA receptors (GABAA receptor) and NaV1.3 receptors (NaV1.3 receptor). In the murine psychomotor seizure test, it demonstrated anticonvulsant activity with an ED50 of 107 mg/kg. Additionally, Compound 5c shows neuroprotective effects against Kainic acid with an IC50 of 113 µM and possesses blood-brain barrier (BBB) permeability.
Target:
Sodium Channel|||GABA Receptor
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