Lipid-lowering agent-2 (Compound 14d) exhibits oral efficacy as a lipid-lowering agent with an EC50 of 0.06 µM. It works by inhibiting lipid synthesis and activating the AMPK signaling pathway, contributing to its anti-obesity effects. Additionally, Lipid-lowering agent-2 suppresses food intake in mice, enhances glucose metabolism, and reduces body weight and adipose tissue in mice induced by a high-fat diet (HFD).
Target:
AMPK
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