PfSUB1-IN-1 (compound 4c) is an inhibitor of Plasmodium falciparum subtilisin-like serine protease 1 (PfSUB1), exhibiting potent activity with an IC50 value of 15 nM. PfSUB1 is a key target in antimalarial research. PfSUB1-IN-1 demonstrates a 13-fold greater inhibitory effect on the growth of transgenic Plasmodium falciparum strains (expressing lower levels of PfSUB1 compared to the wild-type) than on wild-type parasite strains.
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Parasite
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