FOSL1 degrader 1 (4) is a potent T-5224-PROTAC that effectively degrades FOSL1 (AP-1), thereby suppressing the expression of cancer stemness genes in HNSCC. By degrading FOSL1, it inhibits tumor growth and effectively eliminates cancer stem cells in HNSCC tumors. This compound demonstrates an efficacy 30 to 100 times greater than that of T-5224.
Target:
PROTACs|||DNA/RNA Synthesis
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