SMART1 is a CRBN-dependent PROTAC with high specificity that effectively degrades Smurf1. It inhibits tumor growth in xenograft models of colorectal cancer (CRC) with KRAS mutations and blocks the PDK1-Akt signaling pathway in KRAS-mutated colorectal cancer.
Molecular Weight:
753.76
Formula:
C40H35N9O7
Target:
PDK|||Ras|||Kras|||Akt|||PROTACs
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